Study of Cancer Cell Mechanics by Traction Force Microscopy
نویسندگان
چکیده
منابع مشابه
Finite Element Simulation of Contact Mechanics of Cancer Cells in Manipulation Based on Atomic Force Microscopy
The theory of contact mechanics deals with stresses and deformations which arise when the surfaces of two solid bodies are brought into contact. In elastic deformation contact occurs over a finite area. A regular method for determining the dimensions of this area is Hertz Contact Model. Appearance of atomic force microscope results in introduction of Contact ...
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Native cell-material interactions occur on materials differing in their structural composition, chemistry, and physical compliance. While the last two decades have shown the importance of traction forces during cell-material interactions, they have been almost exclusively presented on purely elastic in vitro materials. Yet, most bodily tissue materials exhibit some level of viscoelasticity, whi...
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Cellular forces generated by the actomyosin cytoskeleton and transmitted to the extracellular matrix (ECM) through discrete, integrin-based protein assemblies, that is, focal adhesions, are critical to developmental morphogenesis and tissue homeostasis, as well as disease progression in cancer. However, quantitative mapping of these forces has been difficult since there has been no experimental...
متن کاملThe principles and biological applications of cell traction force microscopy
When a cell adheres to an underlying substrate, it exerts traction forces on the substrate to enable migration. The cell traction forces (CTFs) are also essential for controlling cell shape and maintaining cellular homeostasis. As such, CTF plays a vital role in many fundamental biological processes including morphogenesis, angiogenesis, metastasis, and tissue wound healing. Thus, a close exami...
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Transmission of mechanical force is crucial for normal cell development and functioning. However, the process of mechanotransduction cannot be studied in isolation from cell mechanics. Thus, in order to understand how cells 'feel', we must first understand how they deform and recover from physical perturbations. Owing to its versatility, atomic force microscopy (AFM) has become a popular tool t...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.2956